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KMID : 1123920150290010027
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Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 1 p.27 ~ p.32
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Effects of Aconitum Koreanum Extract on the Growth, Acid Production, Adhesion and Insoluble Glucan Synthesis of Streptococcus Mutans
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Kang Sun-Young
An So-Youn
Lee Min-Woo
Kwon Sim-Kyo
Lee Dong-Hyuk
Jeon Byung-Hoon
Kim Kang-Ju
You Yong-Ouk
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Abstract
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Streptococcus mutans triggers dental caries establishment by two major factors. One is synthesis of organic acids which demineralize dental enamel and the other is synthesis of glucans which mediate the attachment of bacteria to the tooth surface. In the present study, we evaluated the effect of the ethanol extracts of Aconitum koreanum (A. koreanum ) on the growth and acid production of S. mutans. Ethanol extracts of the A. koreanum showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition at the concentration of 0.016 mg/ml compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by 50%, 54% at the concentration of 0.063, 0.125 mg/ml. On the study of activation of glucosyltransferase which synthesizes water insoluble glucan form sucrose, the ethanol extract of A. koreanum showed remarkable inhibition over the concentration of 0.016, 0.031, 0.063 and 0.125 mg/ml (p<0.05). Especially on the concentration of 0.063, 0.125 mg/ml, the extracts suppressed the glucan synthesis by 100%. We analyzed the component of the extracts of A. koreanum . The results showed that the extract of A. koreanum had strong phenolic compound, glycosides and organic acids. These results suggest that A. koreanum may inhibit the caries-inducing properties of S. mutans, and which may be related with strong phenolic compound, glycosides and organic acids.
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KEYWORD
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aconitum koreanum, dental caries, Streptococcus mutans
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